1.
Bioorg Med Chem Lett
; 11(21): 2871-4, 2001 Nov 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11597419
RESUMO
2-(Anilinomethyl)imidazolines with 2'-esters or 2'-amides are potent agonists of the cloned human alpha(1)-adrenoceptors in vitro. The size and shape of the ortho substituent can have significant effects on the potency, efficacy, and subtype selectivity of these 2-(anilinomethyl)imidazolines. alpha(1A)-subtype selective agonists have been identified.